Study to Identify Mechanisms of Resistance to Standard Therapy in Patients With Metastatic Colorectal Cancer

CompletedOBSERVATIONAL
Enrollment

160

Participants

Timeline

Start Date

August 31, 2009

Primary Completion Date

August 31, 2019

Study Completion Date

August 31, 2019

Conditions
Colorectal Cancer
Interventions
OTHER

Needle core biopsies of liver metastasis

No investigational products will be administered to subjects as part of this translational research study. A first-line chemotherapy regimen consisting of FOLFOX, XELOX or FOLFIRI +/- bevacizumab will be administered as per the standard of care at each treating institution. Needle core biopsies of liver metastasis will be collected and banked before the start of chemotherapy and at the time of progression. Additionally, blood samples will be drawn monthly and stored in the tissue biobank.

Trial Locations (15)

Unknown

University Hospital Leuven, Leuven

Hôpital Sacré-Coeur, Montreal

E1C 6Z8

The Moncton Hospital, Moncton

E1C 8X3

Dr. Georges L. Dumont University Hospital, Moncton

M4N 3M5

Sunnybrook Health Sciences Centre, Toronto

M5G 1X5

Mount Sinai Hospital, Toronto

J4V 2H1

Hôpital Charles Lemoyne, Greenfield Park

H1T 2M4

Hôpital Maisonneuve-Rosemont, Montreal

H2L 4M1

Hôpital Notre-Dame, Montreal

H2X 3J4

Hôpital Saint-Luc, Montreal

H3A 1A1

Royal Victoria Hospital, Montreal

H3T 1E2

Jewish General Hospital, Montreal

H3T 1M5

St-Mary's Hospital, Montreal

H4A 3J1

McGill University Health Centre, Montreal

G1R 2J6

Hôtel-Dieu du Québec, Québec

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Exactis Innovation

OTHER

collaborator

Terry Fox Research Institute

OTHER

collaborator

Fonds de la Recherche en Santé du Québec

OTHER_GOV

lead

Jewish General Hospital

OTHER

NCT00984048 - Study to Identify Mechanisms of Resistance to Standard Therapy in Patients With Metastatic Colorectal Cancer | Biotech Hunter | Biotech Hunter