Radiation Therapy and Chemotherapy in Treating Patients With Stage I Bladder Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

37

Participants

Timeline

Start Date

November 30, 2009

Primary Completion Date

March 31, 2021

Study Completion Date

August 15, 2023

Conditions
Bladder Cancer
Interventions
DRUG

cisplatin

60-minute intravenous (IV) infusion of 15 mg/m\^2 on days 1, 2, 3, 15, 16, 17, 29, 30, and 31 of radiation treatment.

DRUG

5-fluorouracil

Continuous IV infusion of 500 mg/m\^2/24 hrs for 5 consecutive days during weeks 1 and 4 of radiation treatment.

DRUG

Mitomycin

IV bolus dose of 12 mg/m\^2 on day 1 of radiation treatment.

RADIATION

Three-Dimensional Conformal Radiation Therapy

Total dose to the gross bladder volume of 61.2 Gy as 34 daily fractions 5 days/week, for approximately 7 weeks.

Trial Locations (13)

21229

St. Agnes Hospital Cancer Center, Baltimore

30308

Emory Crawford Long Hospital, Atlanta

30322

Winship Cancer Institute of Emory University, Atlanta

44203

Barberton Citizens Hospital, Barberton

44460

Cancer Care Center, Incorporated, Salem

44691

Cancer Treatment Center, Wooster

02721

Hudner Oncology Center at Saint Anne's Hospital - Fall River, Fall River

03756-0002

Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center, Lebanon

10003-3803

Beth Israel Medical Center - Petrie Division, New York

44309-2090

Summa Center for Cancer Care at Akron City Hospital, Akron

19111-2497

Fox Chase Cancer Center - Philadelphia, Philadelphia

77555-0361

University of Texas Medical Branch, Galveston

05819

Norris Cotton Cancer Center - North, Saint Johnsbury

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

collaborator

NRG Oncology

OTHER

lead

Radiation Therapy Oncology Group

NETWORK