An Exploratory Trial to Assess the Improvement of Adverse Events in Chronic Myelogenous Leukemia Patients Treated With Imatinib When Switched to Nilotinib Treatment

PHASE4CompletedINTERVENTIONAL
Enrollment

52

Participants

Timeline

Start Date

December 31, 2009

Primary Completion Date

December 31, 2012

Study Completion Date

December 31, 2012

Conditions
Chronic Myelogenous Leukemia
Interventions
DRUG

Nilotinib

Participants received two 150 \[a total of 300 mg at each dosing\] mg nilotinib capsules twice daily (bid) orally every morning and every evening approximately 12 hours apart and two 200 mg capsules \[a total of 400 mg at each dosing\] for patients enrolled prior to Protocol Amendment 1).

Trial Locations (23)

21229

St. Agnes Hospital, Baltimore

34655

Florida Cancer Institute, New Port Richey

38138

The Jones Clinic, Germantown

46107

St. Francis Hospital and Health Centers IndianaBlood&MarrowTransplantn, Beech Grove

60612

Stroger Cook County Hospital John H. Stroger Hospital, Chicago

63110

St. Louis University Cancer Center, St Louis

72205

Hematology Oncology Services of Arkansas SC, Little Rock

72703

Highlands Oncology Group, Fayetteville

75231

Presbyterian Hospital of Dallas TexasOncology@PresbyterianHosp, Dallas

75246

Texas Oncology Texas Oncology - Sugar Land, Dallas

76022

Texas Oncology, P.A., Bedford

77031

MD Anderson Cancer Center/University of Texas, Houston

78229

Cancer Care Centers of South Texas / HOAST CCC of So. TX- San Antonio(2), San Antonio

90033

USC Norris Cancer Center LAC & USC Medical Center, Los Angeles

92064

Southwest Cancer Care Murrieta, Poway

97210

Northwest Cancer Specialists Salmon Creek Office, Portland

97239

Oregon Health Sciences University, Portland

Unknown

Rocky Mountain Cancer Centers RMCC - Aurora, Greenwood Village

*see dep*

Cancer Centers of Florida PA Cancer Centers of FL-Orlando-4, Ocoee

L6R 3J7

Novartis Investigative Site, Brampton

M5G 2M9

Novartis Investigative Site, Toronto

H1T 2M4

Novartis Investigative Site, Montreal

H3A 1A1

Novartis Investigative Site, Montreal

Sponsors
All Listed Sponsors
lead

Novartis Pharmaceuticals

INDUSTRY