40
Participants
Start Date
January 31, 2002
Primary Completion Date
May 31, 2008
Study Completion Date
April 30, 2009
Cyclosporine A
Cyclosporine arm (CyA group) consisted of oral cyclosporine A (CyA) 4-5mg/kg/day (given in two divided doses) for 9 months followed by gradually decreasing dose of cyclosporine (3.75-1.25 mg/kg/day) within the next 9 months. The dosage of concomitant glucocorticoids was driven and tapered according to a single treatment protocol.
Cyclophosphamide
Cyclophosphamide (CPH) therapeutic arm (CPH group) consisted of 8 boluses of intravenous cyclophosphamide (10mg/kg) given within 9 months in subsequently prolonged intervals (2x3weeks, 4x4 weeks, 2x6 weeks) followed by 4-5 oral cyclophosphamide boluses (10mg/d in 6-8 week intervals). The dosage of concomitant glucocorticoids was driven and tapered according to a single treatment protocol.
Department of Nephrology, General Teaching Hospital and First faculty of Medicine, Charles University in Prague, Prague
Institute of Rheumatology, Prague
Department of Rheumatology, Faculty of Medicine, Charles University in Prague, Hradec Králové
Department of Rheumatology, Faculty of Medicine, Palacky University, Olomouc
Ministry of Health, Czech Republic
OTHER_GOV
Charles University, Czech Republic
OTHER
Palacky University
OTHER
Department of Rheumatology, Hospital, Ceske Budejovice, Czech Republic
UNKNOWN
National Institute of Rheumatology, Piestany, Slovakia
UNKNOWN
St. Anna Hospital, Brno, Czech
OTHER
Institute of Rheumatology, Prague
OTHER