A Study of the Safety and Pharmacology Of PI3-Kinase Inhibitor GDC-0941 In Combination With Either Paclitaxel And Carboplatin (With or Without Bevacizumab) or Pemetrexed, Cisplatin, And Bevacizumab in Patients With Advanced Non-Small Cell Lung Cancer

PHASE1CompletedINTERVENTIONAL
Enrollment

65

Participants

Timeline

Start Date

October 31, 2009

Primary Completion Date

March 31, 2015

Study Completion Date

March 31, 2015

Conditions
Non-Squamous Non-Small Cell Lung Cancer
Interventions
DRUG

GDC-0941

The GDC-0941 at a starting dose of 60 milligrams (mg) will be administered once daily orally for 14 consecutive days (Days 1 to 14) in 3-week cycles except for the first cycle that has Day 1 of single-agent GDC-0941 preceding Day 2 with combination chemotherapy.\\n\\n\\n\\n\\n\\n

DRUG

bevacizumab

Bevacizumab 15 milligrams per kilograms (mg/kg) intravenously (IV) on Day 1 of every 3-week cycle.

DRUG

carboplatin

Carboplation IV on Day 1 of every 3-week cycle, at a dose to achieve an area under concentration time curve of 6 milligrams per milliliter\*minute (mg/mL\*min).\\n

DRUG

cisplatin

Cisplatin 75 milligrams per square meter (mg/m\^2) IV on Day 1 of every 3-week cycle.\\n

DRUG

paclitaxel

Paclitaxel 200 mg/m\^2 IV on Day 1 of every 3-week cycle.\\n\\n

DRUG

pemetrexed

Pemetrexed 500 mg/m\^2 IV on Day 1 of every 3-week cycle.

Trial Locations (3)

14263

Buffalo

94805

Villejuif

9700 RB

Groningen

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Genentech, Inc.

INDUSTRY