65
Participants
Start Date
October 31, 2009
Primary Completion Date
March 31, 2015
Study Completion Date
March 31, 2015
GDC-0941
The GDC-0941 at a starting dose of 60 milligrams (mg) will be administered once daily orally for 14 consecutive days (Days 1 to 14) in 3-week cycles except for the first cycle that has Day 1 of single-agent GDC-0941 preceding Day 2 with combination chemotherapy.\\n\\n\\n\\n\\n\\n
bevacizumab
Bevacizumab 15 milligrams per kilograms (mg/kg) intravenously (IV) on Day 1 of every 3-week cycle.
carboplatin
Carboplation IV on Day 1 of every 3-week cycle, at a dose to achieve an area under concentration time curve of 6 milligrams per milliliter\*minute (mg/mL\*min).\\n
cisplatin
Cisplatin 75 milligrams per square meter (mg/m\^2) IV on Day 1 of every 3-week cycle.\\n
paclitaxel
Paclitaxel 200 mg/m\^2 IV on Day 1 of every 3-week cycle.\\n\\n
pemetrexed
Pemetrexed 500 mg/m\^2 IV on Day 1 of every 3-week cycle.
Buffalo
Villejuif
Groningen
Lead Sponsor
Genentech, Inc.
INDUSTRY