Low Dose Intravenous (IV) Infusion of BNP in the Presence and Absence of Acute Type V Phosphodiesterase (PDE V) in Improving Renal Function in Hospitalized Chronic Heart Failure (CHF) Patients With Renal Dysfunction

PHASE1/PHASE2CompletedINTERVENTIONAL

Enrollment

Participants

Timeline

Start Date

October 31, 2009

Primary Completion Date

June 30, 2019

Study Completion Date

December 31, 2019

Conditions

Heart FailureRenal Dysfunction

Interventions

DRUG

BNP and PDE-V

low dose BNP 0.025 u/kg/min for 3 hours then 0.005ug/kg/min 45 hours PDE-V 12.5 mg 4 time points

DRUG

BNP

low dose BNP at 0.025 u/kg/min if tolerated then at 0.005 ug/kg/min for 45 hours