Adjunctive Therapy of Exenatide or Sitagliptin to Insulin Glargine in Type 2 Diabetes

PHASE1CompletedINTERVENTIONAL
Enrollment

48

Participants

Timeline

Start Date

January 31, 2008

Primary Completion Date

September 30, 2008

Study Completion Date

November 30, 2008

Conditions
Type 2 Diabetes
Interventions
DRUG

insulin glargine + exenatide + preexisting metformin

insulin glargine once daily subcutaneously over 4 weeks, dose adjustment according to a treat-to-target algorithm, exenatide 5ug twice daily subcutaneously for 2 weeks, then 10ug twice daily for 2 weeks, continuation of preexisting metformin

DRUG

insulin glargine + sitagliptin + preexisting metformin

insulin glargine once daily subcutaneously over 4 weeks, dose adjustment according to a treat-to-target algorithm, sitagliptin 100 mg once daily in the morning over 4 weeks, continuation of preexisting metformin

DRUG

insulin glargine + preexisting metformin

insulin glargine once daily subcutaneously over 4 weeks, continuation of preexisting metformin

Trial Locations (1)

41460

Profil Institut für Stoffwechselforschung GmbH, Neuss

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Sanofi

INDUSTRY

lead

Profil Institut für Stoffwechselforschung GmbH

INDUSTRY

NCT00971659 - Adjunctive Therapy of Exenatide or Sitagliptin to Insulin Glargine in Type 2 Diabetes | Biotech Hunter | Biotech Hunter