Adjunctive Therapy of Exenatide or Sitagliptin to Insulin Glargine in Type 2 Diabetes

PHASE1CompletedINTERVENTIONAL
Enrollment

48

Participants

Timeline

Start Date

January 31, 2008

Primary Completion Date

September 30, 2008

Study Completion Date

November 30, 2008

Conditions
Type 2 Diabetes
Interventions
DRUG

insulin glargine + exenatide + preexisting metformin

insulin glargine once daily subcutaneously over 4 weeks, dose adjustment according to a treat-to-target algorithm, exenatide 5ug twice daily subcutaneously for 2 weeks, then 10ug twice daily for 2 weeks, continuation of preexisting metformin

DRUG

insulin glargine + sitagliptin + preexisting metformin

insulin glargine once daily subcutaneously over 4 weeks, dose adjustment according to a treat-to-target algorithm, sitagliptin 100 mg once daily in the morning over 4 weeks, continuation of preexisting metformin

DRUG

insulin glargine + preexisting metformin

insulin glargine once daily subcutaneously over 4 weeks, continuation of preexisting metformin

Trial Locations (1)

41460

Profil Institut für Stoffwechselforschung GmbH, Neuss

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Sanofi

INDUSTRY

lead

Profil Institut für Stoffwechselforschung GmbH

INDUSTRY