Everolimus Dose Finding Study for Stage IV or Recurrent Cervical Cancer

PHASE1WithdrawnINTERVENTIONAL
0
Timeline

Start Date

December 31, 2009

Primary Completion Date

December 31, 2010

Study Completion Date

December 31, 2010

Conditions
Cervical Cancer
Interventions
DRUG

RAD001

RAD001 will be administered orally as 5 mg qod, 5 mg qd, or 10mg qd continuously from study Day 1 until the end of whole pelvic radiation therapy unless the patient develops progression of disease or unacceptable toxicity prior to that.

DRUG

Cisplatin

Cisplatin will be administered intravenously once weekly at 40mg/m2 for 6 weeks. The preferred administration day is Monday.

RADIATION

External Beam Whole Pelvis Radiation Therapy

Patients will receive 180 cGy daily fraction Monday through Friday x 25 days (4500 cGy total) using a four field technique throughout the entire treatment with all fields treated each day.

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Novartis Pharmaceuticals

INDUSTRY

lead

Accelerated Community Oncology Research Network

OTHER