Safety/Efficacy Study of Optimizing Ibuprofen Dosing to Achieve Higher PDA Closure Rates

PHASE4TerminatedINTERVENTIONAL
Enrollment

10

Participants

Timeline

Start Date

August 31, 2009

Primary Completion Date

October 31, 2010

Study Completion Date

October 31, 2010

Conditions
Patent Ductus Arteriosus
Interventions
DRUG

optimized ibuprofen

day of life 0-3 - 10, 5, 5 mg/kg/dose at 24 hour intervals day of life 4-6 - 14, 7, 7 mg/kg/dose at 24 hour intervals day of life 7-29 - 20, 10, 10 mg/kg/dose at 24 hour intervals

DRUG

Standard Ibuprofen

day of life 0-29 - 10,5, 5 mg/kg/dose at 24 hour intervals

Trial Locations (1)

61637

Children's Hospital of Illinois at OSF Saint Francis Medical Center, Peoria

Sponsors
All Listed Sponsors
lead

OSF Healthcare System

OTHER