30
Participants
Start Date
November 30, 2008
Primary Completion Date
March 31, 2016
Study Completion Date
July 31, 2016
Topotecan hydrochloride
The topotecan hydrochloride is administered intravenously over five days to dose of 0.7 mg/ m²/day from day 1 to day 5 (first cycle), then from day 21 to day 25 (second cycle)
Autologous hematopoietic stem cell transplantation
Hematopoietic stem cells are reinjected 10 days after the second injection of 131-iodine MIBG
iobenguane I 131
444 MBq / kg of 131-iodine MIBG is administered on day 1 with activity
total-body irradiation
the dose of total-body irradiation of 4 Gy is reached during the first cycle, the second cycle is canceled (131-iodine MIBG and Topotecan)
Hôpital des Enfants, Toulouse
Centre Oscar Lambret, Lille
Centre Léon Bérard, Lyon
Collaborators (1)
National Cancer Institute, France
OTHER_GOV
Novartis Pharmaceuticals
INDUSTRY
Centre Oscar Lambret
OTHER