17
Participants
Start Date
March 31, 2010
Primary Completion Date
August 31, 2011
Study Completion Date
August 31, 2011
HPN-100
HPN-100 is a triglyceride that has a similar mechanism of action as NaPBA. It is a liquid with minimal taste and odor. Three teaspoons of HPN-100 (\~17.4mL) delivers equivalent amount of PBA that 40 tablets of NapBA do.
NaPBA
NaPBA tablets for oral administration and NaPBA powder for oral, nasogastric, or gastrostomy tube administration contain the active ingredient sodium phenylbutyrate. NaPBA is a prodrug and is rapidly metabolized to PAA, the metabolically active compound that conjugates with glutamine via acetylation to form PAGN, which is excreted by the kidneys.
Mount Sinai School of Medicine, New York
University of Pittsburgh, Pittsburgh
The George Washington DC Children's National Medical Center, Washington D.C.
Medical College of Wisconsin, Milwaukee
Baylor College of Medicine, Houston
UCLA, Los Angeles
Seattle Children's Hospital, Seattle
The Hospital for Sick Children, Toronto
Lead Sponsor
Amgen
INDUSTRY