Dual Epidermal Growth Factor Receptor Inhibition With Erlotinib and Panitumumab With or Without Chemotherapy for Advanced Colorectal Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

28

Participants

Timeline

Start Date

January 18, 2010

Primary Completion Date

January 31, 2015

Study Completion Date

January 31, 2015

Conditions
Colorectal Cancer
Interventions
BIOLOGICAL

panitumumab

Given intravenously 6mg/kg every 2 weeks

DRUG

erlotinib hydrochloride

Given orally 150mg daily

DRUG

irinotecan hydrochloride

Given intravenously 120mg/m2 for 6/6 genotype and 60mg/m2 for 6/7 genotype

Trial Locations (10)

38138

The Jones Clinic, Germantown

47802

Hope Cancer Center, Terre Haute

60005

Cancer Care & Hematology Specialists of Chicagoland, Arlington Heights

60435

Joliet Oncology-Hematology Associates, Ltd., Joliet

60611

Hematology/Oncology Associates, Chicago

67214

Cancer Center of Kansas, Wichita

68114

Nebraska Methodist Hospital, Omaha

60611-3013

Northwestern University, Northwestern Medical Faculty Foundation, Chicago

08060

Virtua Memorial (Regional Cancer Care Associates of Mount Holly), Mount Holly

73120-9309

Mercy Clinic Oncology and Hematology, Oklahoma City

All Listed Sponsors
collaborator

Genentech, Inc.

INDUSTRY

collaborator

OSI Pharmaceuticals

INDUSTRY

collaborator

Amgen

INDUSTRY

lead

Northwestern University

OTHER