A Clinical Study to Evaluate the Pharmacokinetics and the Absolute Bioavailability of SRT2104 Given as a 250mg Oral Suspension and Intravenous Microdose of 100 µg Carbon-14 Radio-labeled SRT2104 in Healthy Male Subjects

PHASE1CompletedINTERVENTIONAL
Enrollment

9

Participants

Timeline

Start Date

November 22, 2008

Primary Completion Date

December 22, 2008

Study Completion Date

December 22, 2008

Conditions
Diabetes Mellitus, Type 2
Interventions
DRUG

250 mg SRT2104 Suspension

Single 10 mL oral dose of 250 mg SRT2104 delivered as a suspension formulation.

DRUG

Carbon-14 radio-labeled SRT2104

Single 10 mL IV dose containing 100 microgram (not more than 250 nCi, 9.25 kBq) Carbon-14 radio-labeled SRT2104, administered by IV infusion over 15 minutes, starting 2 hours and 45 minutes after the oral dose is administered.

Trial Locations (1)

NG11 6JS

GSK Investigational Site, Nottingham

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

GlaxoSmithKline

INDUSTRY

lead

Sirtris, a GSK Company

INDUSTRY