Initial Dosage Range of Tacrolimus by Genotyping in Chinese Renal Transplantation

PHASE4CompletedINTERVENTIONAL
Enrollment

145

Participants

Timeline

Start Date

July 31, 2009

Primary Completion Date

December 31, 2010

Study Completion Date

June 30, 2011

Conditions
Renal Transplantation
Interventions
DRUG

Tacrolimus

The genotyping of gene CYP3A5 will be carried out in the 4-7days before renal transplantation. After transplantation, the patients will be treated by MMF, corticosteroids and tacrolimus at a dosage adapted to their genotype(CYP3A5\*1/\*1 type and CYP3A5\*1/\*3 type administer 0.15mg/kg/d,CYP3A5\*3/\*3 type administer 0.08mg/kg/d).

Trial Locations (5)

100020

Chaoyang Hospital, affiliated Hospital of Capital Medical University, Beijing

100036

General Hospital of Air Force of Chinese PLA, Beijing

100088

The Second Artillery Gernal Hospital, Beijing

200003

Changzheng Hospital, the Second Affiliated Hospital of the Second Military Medical University, Shanghai

450052

The First Affiliated Hospital of Zhengzhou University, Zhengzhou

Sponsors
All Listed Sponsors
collaborator

Capital Medical University

OTHER

collaborator

Shanghai Changzheng Hospital

OTHER

collaborator

Pharmacology Research Institute

OTHER

collaborator

Air Force General Hospital of the PLA

OTHER_GOV

collaborator

Health Department of General Logistics

UNKNOWN

lead

The Second Artillery General Hospital

OTHER

NCT00935298 - Initial Dosage Range of Tacrolimus by Genotyping in Chinese Renal Transplantation | Biotech Hunter | Biotech Hunter