A Study to Evaluate Safety and Tolerability of Multiple Doses of MEDI-546 in Adult Subjects With Scleroderma

0.1 mg/kg MEDI-546 as a single IV dose

0.3 mg/kg MEDI-546 as a single IV dose

1.0 mg/kg MEDI-546 as a single IV dose

3.0 mg/kg MEDI-546 as a single IV dose

10.0 mg/kg MEDI-546 as a single IV dose

0.3 mg/kg MEDI-546 as a weekly IV dose x 4 doses

1.0 mg/kg MEDI-546 as a weekly IV dose x 4 doses

5.0 mg/kg MEDI-546 as a weekly IV dose x 4 doses

20.0 mg/kg MEDI-546 as a single IV dose