Trial of Dasatinib Plus Ixabepilone in 2nd or 3rd Line Metastatic Breast Cancer

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

56

Participants

Timeline

Start Date

June 30, 2009

Primary Completion Date

October 31, 2013

Study Completion Date

October 31, 2013

Conditions
Metastatic Breast Cancer
Interventions
DRUG

Dasatinib

Dasatinib tablets will be administered continuously starting on Day 1, Cycle 1 once daily (QD).Dose Level 2;140 mg QD,Dose Level 1;100 mg QD,Dose Level 0 (Starting Dose);100 mg QD,Dose Level - 1;100 mg QD,Dose Level - 2;70 mg QD.

DRUG

Ixabepilone

Ixabepilone, for injection 15 mg supplied with diluent for ixabepilone, 8 mL. Dose Level 2;20 mg/m2,Dose Level 1;20 mg/m2,Dose Level 0 (Starting Dose);16 mg/m2,Dose Level - 1;12 mg/m2,Dose Level - 2;12 mg/m2.

Trial Locations (13)

19106

Pennsylvania Oncology Hematology Associates, Philadelphia

27403

The Moses H. Cone Regional Cancer Center, Greensboro

30060

Northwest Georgia Oncology Centers, Marietta

31201

Central Georgia Cancer Care, Macon

38104

University of Tennessee Cancer Institute, Memphis

38120

The West Clinic, Memphis

44870

North Coast Cancer Care, Sandusky

52722

Hematology Oncology Associates of the Quad Cities, Bettendorf

59101

Hematology Oncology Centers of the Northern Rockies, Billings

60076

North Shore Cancer Research, Skokie

06902

Hematology Oncology PC, Stamford

01107

Baystate Medical Center, Springfield

07834

Oncology Hematology Specialists, P.A., Denville

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

lead

Accelerated Community Oncology Research Network

OTHER