Desensitization in Kidney Transplantation

PHASE4CompletedINTERVENTIONAL
Enrollment

44

Participants

Timeline

Start Date

May 31, 2009

Primary Completion Date

November 30, 2012

Study Completion Date

November 30, 2012

Conditions
HLA Sensitization
Interventions
DRUG

plasmapheresis

Patients will receive plasmapheresis 1.5 x plasma volume prior to each Bortezomib dose. Plasma volume replacement will be per physician discretion.

DRUG

Bortezomib

Patients will receive bortezomib as described in protocol

DRUG

Rituximab

Patients will receive rituximab as described in protocol

DRUG

Methylprednisolone

Each bortezomib dose will be preceded by intravenous methylprednisolone (100mg for first two doses and 50mg for following doses).

Trial Locations (2)

45267

The Christ Hospital, Cincinnati

University of Cincinnati, Cincinnati

Sponsors
All Listed Sponsors
collaborator

Millennium Pharmaceuticals, Inc.

INDUSTRY

lead

University of Cincinnati

OTHER