Trial of Fulvestrant, MK-0646, and Dasatinib for Metastatic Hormone Receptor-Positive HER2-Negative Breast Cancer

PHASE1/PHASE2TerminatedINTERVENTIONAL
Enrollment

11

Participants

Timeline

Start Date

November 30, 2009

Primary Completion Date

May 31, 2013

Study Completion Date

May 31, 2013

Conditions
Breast Cancer
Interventions
DRUG

Fulvestrant

Starting dose of 500 mg through a needle into muscle on Days 1 and 15 of Cycle 1 and on Day 1 of Cycles 2 and beyond. On Day 1 of Cycle 1, injections into 2 different muscles, all other times one injection.

DRUG

MK-0646

Group 3 or Group 4, receive starting dose of 5 mg/kg by vein on Days 1, 18, 15, and 22 of every cycle.

DRUG

Dasatinib

Group 2 or Group 4, starting dose of 70 mg (capsules) by mouth daily.

Trial Locations (1)

77030

UT MD Anderson Cancer Center, Houston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

collaborator

Merck Sharp & Dohme LLC

INDUSTRY

collaborator

Commonwealth Foundation for Cancer Research

UNKNOWN

lead

M.D. Anderson Cancer Center

OTHER

NCT00903006 - Trial of Fulvestrant, MK-0646, and Dasatinib for Metastatic Hormone Receptor-Positive HER2-Negative Breast Cancer | Biotech Hunter | Biotech Hunter