Nexavar-Tarceva Combination Therapy for First Line Treatment of Patients Diagnosed With Hepatocellular Carcinoma

PHASE3CompletedINTERVENTIONAL
Enrollment

732

Participants

Timeline

Start Date

May 21, 2009

Primary Completion Date

April 17, 2012

Study Completion Date

May 23, 2018

Conditions
Carcinoma, Hepatocellular
Interventions
DRUG

Sorafenib (Nexavar, BAY43-9006)

Sorafenib 400 mg twice daily

DRUG

Erlotinib (Tarceva)

Erlotinib 150 mg once daily

DRUG

Placebo

Matching erlotinib placebo 150 mg once daily

Trial Locations (127)

112

Taipei

333

Taoyuan District

736

Tainan City

1023

Auckland

1090

Vienna

1200

Bruxelles - Brussel

1784

Sofia

2031

Randwick

2193

Johannesburg

2650

Edegem

3000

Leuven

3004

Melbourne

3168

Clayton

4000

Liège

4002

Plovdiv

4029

Herston

4120

Brisbane

6009

Nedlands

6021

Wellington South

7100

La Louvière

7500

Cape Town

8011

Christchurch

8500

Kortrijk

9000

Ghent

9002

Varna

9010

Varna

10029

New York

10595

Valhalla

12200

Berlin

13005

Marseille

14642

Rochester

19107

Philadelphia

20007

Washington D.C.

20089

Milan

21202

Baltimore

27003

Lugo

28040

Madrid

28203

Charlotte

30318

Atlanta

30625

Hanover

32610

Gainesville

33000

Bordeaux

33136

Miami

33604

Pessac

39008

Santander

40202

Louisville

41100

Larissa

45147

Essen

46010

Valencia

46026

Valencia

48202

Detroit

50937

Cologne

54511

Vandœuvre-lès-Nancy

54642

Thessaloniki

55131

Mainz

55455

Minneapolis

59037

Lille

60590

Frankfurt am Main

66205

Westwood

66421

Homburg

69004

Lyon

70112

New Orleans

70300

Zrifin

72076

Tübingen

75012

Paris

77030

Houston

79106

Freiburg im Breisgau

81675

München

85925

La Roche-sur-Yon

92110

Clichy

93042

Regensburg

94010

Créteil

94115

San Francisco

94800

Villejuif

96817

Honolulu

100021

Beijing

100071

Beijing

115478

Moscow

169610

Singapore

210002

Nanjing

308433

Singapore

310016

Hangzhou

510060

Guangzhou

603001

Nizhny Novgorod

656049

Barnaul

3109601

Haifa

4941492

Petah Tikva

7601003

Santiago

7610001

Rehovot

8410101

Beersheba

60153-5585

Maywood

02114

Boston

02215-5450

Boston

01655

Worcester

98109-1023

Seattle

30110-090

Belo Horizonte

90020-090

Porto Alegre

05651-900

São Paulo

21941-913

Rio de Janeiro

01509-900

São Paulo

05403-000

São Paulo

T6G 1Z2

Edmonton

H3A 1A1

Montreal

838-0455

Santiago

Unknown

Floridablanca

Medellín

Hong Kong

Shatin

115 27

Athens

546 36

Thessaloniki

LIMA 1

Lima

LIMA 34

Lima

85-796

Bydgoszcz

80-952

Gdansk

44-101

Gliwice

02-781

Warsaw

410-769

Goyang-si

03080

Seoul

05505

Seoul

06351

Seoul

152-703

Seoul

08907

L'Hospitalet de Llobregat

08036

Barcelona

S10 2SJ

Sheffield

G12 0YN

Glasgow

SE5 9RS

London

NE7 7DN

Newcastle upon Tyne

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Bayer

INDUSTRY