Safety Profile, MTD, and PK Profile Studies of ABT-263 When Administered in Combination With Standard and Weekly Regimens of Docetaxel in Subjects With Cancer

PHASE1CompletedINTERVENTIONAL
Enrollment

41

Participants

Timeline

Start Date

July 31, 2009

Primary Completion Date

March 31, 2012

Study Completion Date

March 31, 2012

Conditions
Solid Tumor
Interventions
DRUG

ABT-263

150 mg of ABT-263 is taken orally once daily on Days 1-5 or Days 1-3 of each 21 day cycle. 150 mg of ABT-263 on Days 1-3, 8-10 and 15-17 of each 28-day cycle. This is a dose escalation study, therefore the dose of ABT-263 will change throughout the study.

DRUG

Docetaxel

75 mg/m2 will be given by intravenous infusion on day 1 of each 21 -day cycle. 30 mg/m2 will be given by intravenous infusion on day 1, 8, 15 of each 28 -day cycle.

Trial Locations (6)

21231

Site Reference ID/Investigator# 43962, Baltimore

33308

Site Reference ID/Investigator# 44182, Fort Lauderdale

85258

Site Reference ID/Investigator# 51982, Scottsdale

3015 CE

Site Reference ID/Investigator# 12844, Rotterdam

Site Reference ID/Investigator# 20042, Rotterdam

SM2 5PT

Site Reference ID/Investigator# 12845, Surrey

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Genentech, Inc.

INDUSTRY

lead

Abbott

INDUSTRY