Safety/Biomarker Study of CNTO 95 and Avastin in Solid Tumors

PHASE1CompletedINTERVENTIONAL
Enrollment

13

Participants

Timeline

Start Date

March 31, 2009

Primary Completion Date

December 31, 2014

Study Completion Date

January 31, 2015

Conditions
Solid Tumors
Interventions
DRUG

CNTO 95 and avastin

"STAGE 1 (Dose escalation) Cohort # subjects CNTO 95 Bevacizumab~* 2 3-6 2.5 mg/kg IV Q3 weeks 7.5 mg/kg IV Q3 weeks~* 1 3-6 2.5 mg/kg IV Q3 weeks 15 mg/kg IV Q3 weeks~ 1. 3-6 5 mg/kg IV Q3weeks 15 mg/kg IV Q3 weeks~ 2. 3-6 10 mg/kg IV Q3 weeks 15 mg/kg IV Q3 weeks STAGE 2 (Biomarker) Cohort # subjects CNTO 95 Bevacizumab~ 3. 20 Recommended Phase II Dose Recommended Phase II Dose"

Trial Locations (1)

27705

Duke University Medical Center, Durham

Sponsors
All Listed Sponsors
collaborator

Centocor, Inc.

INDUSTRY

collaborator

Genentech, Inc.

INDUSTRY

lead

Herbert Hurwitz, MD

OTHER