Neoadjuvant Sunitinib With Paclitaxel/Carboplatin in Patients With Triple-Negative Breast Cancer

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

54

Participants

Timeline

Start Date

June 30, 2009

Primary Completion Date

July 31, 2013

Study Completion Date

September 30, 2014

Conditions
Breast Cancer
Interventions
DRUG

Paclitaxel

IV infusion per institutional guidelines on Days 1, 8 and 15 of a 28 day cycle as follows depending on dose level (DL): DL1- 70 mg/m2, DL2- 80 mg/m2, DL3- 80mg/m2, DL4- 80mg/m2, DL-1- 70mg/m2, DL-2- 60mg/m2

DRUG

Carboplatin

IV infusion per institutional guidelines Day 1 of a 28 day cycle as follows depending on dose level (DL): DL1- AUC=5, DL2- AUC=5, DL3- AUC=6, DL4- AUC=6, DL-1- AUC=4, DL-2- AUC=4

DRUG

Sunitinib

By mouth (PO) once daily on days 1-21 of a 28 day cycle as follows depending on dose level (DL): DL1- 25mg, DL2-25mg, DL3- 25mg, DL4- 37.5mg, DL-1- 25mg, DL-2- 25mg. Maintenance therapy of 25mg daily

Trial Locations (14)

20817

Center for Cancer and Blood Disorders, Bethesda

National Capital Clinical Research Consortium, Bethesda

30501

Northeast Georgia Medical Center, Gainesville

33308

Holy Cross Hospital, Fort Lauderdale

33916

Florida Cancer Specialists North, Fort Myers

Florida Cancer Specialists South, Fort Myers

37023

Tennessee Oncology, PLLC, Nashville

38017

Family Cancer Center, Collierville

40207

Baptist Hospital East, Louisville

47802

Providence Medical Group, Terre Haute

63017

St. Louis Cancer Care, Chesterfield

68114

Nebraska Methodist Cancer Center, Omaha

73505

Cancer Centers of Southwest Oklahoma, Lawton

07960

Hematology Oncology Associates of Northern NJ, Morristown

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Pfizer

INDUSTRY

lead

SCRI Development Innovations, LLC

OTHER

NCT00887575 - Neoadjuvant Sunitinib With Paclitaxel/Carboplatin in Patients With Triple-Negative Breast Cancer | Biotech Hunter | Biotech Hunter