5-aza-2-deoxycytidine With Pegylated Interferon-alfa 2B: A Phase I Study With Molecular Correlates

PHASE1TerminatedINTERVENTIONAL
Enrollment

3

Participants

Timeline

Start Date

April 30, 2009

Primary Completion Date

August 31, 2010

Study Completion Date

October 31, 2010

Conditions
Cancer
Interventions
DRUG

Decitabine and Pegylated Interferon-Alfa 2B

Patients will receive decitabine 3.7 mg/m2/day i.v. over 1 hour daily in 10 doses over 2 weeks elapsed time (Monday-Friday) every 28 days plus fixed dose of PEG-Intron (0, 0.5, 1.5, 3 or 6 mcg/kg PEG-Intron) weekly by subcutaneous injection in 28-day cycles .

Trial Locations (1)

89135

Nevada Cancer Institute, Las Vegas

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

National Institutes of Health (NIH)

NIH

collaborator

Schering-Plough

INDUSTRY

lead

Nevada Cancer Institute

OTHER