Cardiomyopathy in Steroid-resistant Nephrotic Syndrome: Impact of Focal Segmental Glomerulosclerosis

TerminatedOBSERVATIONAL
Enrollment

4

Participants

Timeline

Start Date

October 31, 2008

Primary Completion Date

August 31, 2011

Study Completion Date

October 31, 2011

Conditions
Focal Segmental GlomerulosclerosisNephrotic SyndromeSteroid Resistant Nephrotic SyndromeChronic Kidney Disease
Interventions
OTHER

Cardiovascular Assessment

Measure of BNP, and Pro-BNP Complete 2 Dimensional Echocardiogram with Doppler evaluation including determination of, Left Ventricular mass, Ejection fraction, Midwall fractional shortening, velocity of early and late diastolic transmitral flow, and measurement of E/A ratio, Ratio of end-systolic wall stress to rate corrected velocity of circumferential fiber shortening.

OTHER

Renal Assessment

Complete a metabolic panel, CMP. Calculation of glomerular filtration rate, GFR, measure of urinary total protein, albumin and creatinine excretion in a first morning urine sample, 24 hour blood pressure monitoring,

OTHER

Genetic Evaluation

All patients will undergo genetic screening for all known podocyte gene mutations.

Trial Locations (1)

11040

Schneider Children's Hospital, New Hyde Park

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Northwell Health

OTHER

NCT00883636 - Cardiomyopathy in Steroid-resistant Nephrotic Syndrome: Impact of Focal Segmental Glomerulosclerosis | Biotech Hunter | Biotech Hunter