Safety of MP470 in Combination With Standard-of-Care Chemotherapy Regimens to Treat Solid Tumors

Topotecan 1.5 mg/m2 IV infusion over 30 minutes on Days 1-5

Docetaxel 75 mg/m2 IV infusion over 1 hour on Day 1

150 mg PO once daily at least 1 hour before or 2 hours after eating

Paclitaxel 200 mg/m2 IV infusion over 3 hours followed by carboplatin IV infusion over 1 hour to a target AUC of 6 mg∙min/mL on Day 1

Carboplatin IV infusion over 1 hour to target AUC of 5 mg min/mL on Day 1 followed by etoposide 100 mg/m2 IV infusion over 2 hours on Days 1-3