Trial for Patients Not Qualifying for TT4 and TT5 Protocols Because of Prior Therapy

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

160

Participants

Timeline

Start Date

March 31, 2009

Primary Completion Date

December 31, 2026

Study Completion Date

December 31, 2026

Conditions
Myeloma
Interventions
DRUG

Melphalan

"Given by vein, Day 3~First Inter-Therapy Treatment Bortezomib (Velcade) By vein Days 1 and 4~Second Inter-Therapy Treatment Bortezomib (Velcade) By vein Days 1 and 4~Second Transplant Bortezomib (Velcade) By vein Day -5 and Day -2~Year 1 Maintenance Velcade (bortezomib) By vein Days 1, 8, 15, 22(weekly) Every 28 days~Years 2 \& 3 Maintenance Velcade (bortezomib) By vein Days 1, 8, 15, 22(weekly) Every 56 days"

DRUG

Velcade

Given by vein, Days 1, 5, 8, 11

DRUG

Thalidomide

Given by mouth at bedtime, Days 5-8

DRUG

Dexamethasone

Given by mouth, once per day Days 5-8

DRUG

Cisplatin

Given by vein, Days 5-8 continuous infusion

DRUG

Adriamycin

Given by vein, days 5-8 continuous infusion

DRUG

Cyclophosphamide

Given by vein days 5-8 continuous infusion

DRUG

Etoposide

Given by vein days 5-8 continuous infusion

Trial Locations (1)

72205

University of Arkansas for Medical Sciences, Little Rock

All Listed Sponsors
lead

University of Arkansas

OTHER