Initiating Transdermal Estradiol Therapy in Turner's Syndrome

PHASE1TerminatedINTERVENTIONAL
Enrollment

1

Participants

Timeline

Start Date

April 30, 2009

Primary Completion Date

March 31, 2011

Study Completion Date

March 31, 2011

Conditions
Turner's Syndrome
Interventions
DRUG

Norditropin, Menostar 14mcg patch, Vivelle dot 25mcg patch

GH will be maintained at 0.05mg/kg/d, adjusted every 3 months. Estradiol 14mcg patch will be applied for 10 days/month for the first 6 months in Group 2. Estradiol 25mcg patch will be applied for 10 days/month for the second 6 months in Group 2, and for the first 6 months in Group 3. Estradiol 25mcg patch will be applied for 3 weeks per month for the second 6 months in Group 3.

Trial Locations (3)

21287

John Hopkins University, Baltimore

48109

University of Michigan, Ann Arbor

60637

University of Chicago, Chicago

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Novo Nordisk A/S

INDUSTRY

collaborator

University of Michigan

OTHER

collaborator

Johns Hopkins University

OTHER

collaborator

Massachusetts General Hospital

OTHER

collaborator

University of Oklahoma

OTHER

collaborator

University of South Florida

OTHER

collaborator

Thomas Jefferson University

OTHER

lead

University of Chicago

OTHER