45
Participants
Start Date
October 31, 1994
Primary Completion Date
July 31, 1999
Study Completion Date
February 28, 2009
CEEP regimen
cyclophosphamide 1200 mg/m² intravenously on day 1 (d1), epirubicin 100 mg/m² intravenously on d1, vindesine 3 mg/m² intravenously on d1 and prednisone 80 mg/m² orally or intravenously on d1-5, with two weeks intervals
Tandem high-dose therapy (HDT) followed by autologous peripheral blood stem cell (PBSC)
"The conditioning regimen of the first HDT was mitoxantrone 45 mg/m² intravenously on d1 + cytarabine 1000 mg/m² by a 3-hour infusion every 12 hours from d1-4.~The conditioning regimen of the second HDT started d30 to d45 after the first stem cell infusion, and consisted of 1200 cGy total body irradiation (TBI) in 6 twice daily 200 cGy fractionated doses with a 800 cGy pulmonary shielding, followed by CBV: carmustine 300 mg/m² intravenously on d4, etoposide 200 mg/m² intravenously on d5-8 and cyclophosphamide 1500 mg/m² intravenously on d5-8."
Emmanuel Gyan, Tours
Collaborators (1)
Amgen
INDUSTRY
French Innovative Leukemia Organisation
OTHER