Study of ABT-263 When Administered in Combination With Either Fludarabine/Cyclophosphamide/Rituximab or Bendamustine/Rituximab in Relapsed or Refractory Chronic Lymphocytic Leukemia

PHASE1CompletedINTERVENTIONAL
Enrollment

32

Participants

Timeline

Start Date

November 30, 2009

Primary Completion Date

May 31, 2013

Study Completion Date

May 31, 2013

Conditions
Chronic Lymphocytic Leukemia
Interventions
DRUG

ABT-263

ABT-263 is taken orally once daily for 3 days out of each 28 day cycle. This is a dose escalation study, therefore the dose of ABT-263 will change throughout the study.

DRUG

FCR

Rituximab will be given by intravenous infusion for 1 day out of each 28 day cycle; Fludarabine will be given by intravenous infusion for 3 days out of each 28 day cycle; and Cyclophosphamide will be given by intravenous infusion for 3 days out of each 28 day cycle

DRUG

BR

Rituximab will be given by intravenous infusion for 2 days out of each 28 day cycle and Bendamustine will be given by intravenous infusion for 2 days out of each 28 day cycle

Trial Locations (6)

19111

Site Reference ID/Investigator# 39613, Philadelphia

43210

Site Reference ID/Investigator# 21621, Columbus

92093

Site Reference ID/Investigator# 17841, La Jolla

94305-5821

Site Reference ID/Investigator# 25899, Stanford

21231-1000

Site Reference ID/Investigator# 21622, Baltimore

77030-4009

Site Reference ID/Investigator# 17943, Houston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Genentech, Inc.

INDUSTRY

lead

AbbVie (prior sponsor, Abbott)

INDUSTRY