Study of Modified FOLFOX6 Plus or Minus Sorafenib in Stage IV Metastatic Colorectal Carcinoma (mCRC) Subjects

PHASE2CompletedINTERVENTIONAL
Enrollment

198

Participants

Timeline

Start Date

March 31, 2009

Primary Completion Date

January 31, 2011

Study Completion Date

February 29, 2012

Conditions
Metastatic Colorectal Cancer
Interventions
DRUG

Sorafenib (Nexavar, BAY43-9006) + mFOLFOX6 (5-FU, levo-leucovorin, oxaliplatin)

Subjects will receive oral Sorafenib 400 mg twice daily (BID) continuously and intravenous (IV) mFOLFOX6 (5-FU 400 mg/m\^2 bolus and 2400 mg/m\^2 for 46-48 hrs; levo-leucovorin 200 mg/m\^2; 85 mg/m\^2 oxaliplatin) every 14 days until progressive disease (PD)

DRUG

Matching placebo + mFOLFOX6 (5-FU, levo-leucovorin, oxaliplatin)

Subjects will receive oral matching placebo 2 tablets BID continuously and IV mFOLFOX6 (5-FU 400 mg/m\^2 bolus and 2400 mg/m\^2 for 46-48 hrs; levo-leucovorin 200 mg/m\^2; 85 mg/m\^2 oxaliplatin) every 14 days until progressive disease

Trial Locations (116)

1000

Bruxelles - Brussel

1032

Budapest

1070

Bruxelles - Brussel

1097

Budapest

1106

Budapest

2020

Antwerp

3000

Leuven

4000

Liège

4032

Debrecen

6000

Kecskemét

6720

Szeged

8000

Székesfehérvár

9000

Ghent

9024

Győr

10153

Torino

16132

Genova

18009

Cherkassy

28041

Madrid

29010

Málaga

31033

Castelfranco Veneto

33100

Udine

33170

Pordenone

37134

Verona

39008

Santander

40005

Sumy

41013

Seville

46009

Valencia

46010

Valencia

49055

Dnipropetrovsk

49102

Dnipro

50048

Kryvyi Rih

61070

Kharkiv

62100

Macerata

67214

Wichita

70006

Metairie

75246

Dallas

76000

Ivano-Frankivsk

79031

Lviv

83092

Donetsk

87500

Mariupol

88014

Uzhhorod

90146

Palermo

91047

Luhansk

115478

Moscow

121356

Moscow

129128

Moscow

150054

Yaroslavl

153013

Ivanovo

163045

Arkhangelsk

167904

Syktyvkar

191104

Saint Petersburg

194291

Saint Petersburg

197022

Saint Petersburg

197110

Saint Petersburg

198255

Saint Petersburg

200535

Craiova-Dolj

249036

Obninsk

300053

Tula

300239

Timișoara

305035

Kursk

350040

Krasnodar

350086

Rostov-on-Don

354057

Sochi

357502

Pjatygorsk

400015

Cluj-Napoca

400138

Volgograd

410032

Oradea

414041

Astrakhan

420029

Kazan'

426009

Izhevsk

430031

Baia Mare

432063

Ulyanovsk

443031

Samara

454087

Chelyabinsk

455001

Magnitogorsk

510039

Alba Iulia

600020

Vladimir

603001

Nizhny Novgorod

620036

Yekaterinburg

630047

Novosibirsk

664035

Irkutsk

680022

Khabarovsk

700106

Iași

720237

Suceava

02301

Brockton

01805

Burlington

15-027

Bialystok

82-300

Elblag

80-952

Gdansk

81-519

Gdynia

31-115

Krakow

31-501

Krakow

10-228

Olsztyn

02-781

Warsaw

04-141

Warsaw

53-413

Wroclaw

022326

Bucharest

022328

Bucharest

08035

Barcelona

08036

Barcelona

08907

L'Hospitalet de Llobregat

08240

Manresa

07010

Palma de Mallorca

03022

Kiev

BS2 8ED

Bristol

M20 4BX

Manchester

L7 8XP

Liverpool

HA6 2RN

Northwood

NG5 1PB

Nottingham

AB25 2ZN

Aberdeen

BT7 1NN

Belfast

G61 1BD

Glasgow

HU8 9HE

Hull

WC1E 6BT

London

NE7 7DN

Newcastle upon Tyne

PO6 3LY

Portsmouth

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Amgen

INDUSTRY

lead

Bayer

INDUSTRY

NCT00865709 - Study of Modified FOLFOX6 Plus or Minus Sorafenib in Stage IV Metastatic Colorectal Carcinoma (mCRC) Subjects | Biotech Hunter | Biotech Hunter