Nilotinib and Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

"1. Induction:~ * Daunorubicin 90 mg/m2/day by continuous iv infusion (d1-3)~ * Vincristine 2 mg iv push (d1, 8, 15, 22)~ * Prednisolone 60 mg/m2/day po (d1-28)~ * Nilotinib 400mg bid/d (d8-)~2. Consolidation A (cycle1)~ * Daunorubicin 45 mg/m2/day by continuous iv (d1, 2)~ * Vincristine 2 mg iv (d1, 8)~ * Prednisolone 60 mg/m2/day po (d1-14)~ * Nilotinib 400mg bid/d~3. Consolidation B (cycles 2\&4)~ * Cytarabine 2,000 mg/m2/day iv over 2 hours (d1-4)~ * Etoposide 150 mg/m2/day iv over 3 hours (d1-4)~ * Nilotinib 400mg bid/d~4. Consolidation C (cycles 3\&5)~ * Methotrexate 220 mg/m2 iv bolus, then 60mg/m2/h for 36 hours (d1-2, 15-16)~ * Leucovorin followed immediately by 50 mg/m2 iv every 6hrs for three doses,~ * Nilotinib 400mg bid/d~5. Maintenance~ ◦Nilotinib 400mg bid/d (during 2 years, for patients without alloHCT)~6. Consider alloHCT"