A Study in Normal Healthy People, Testing Different Versions of a Pill That Will be Used to Treat Rheumatoid Arthritis.

one 250mg tablet, once in the morning in fasted state

2x250 mg tablets, once in the morning, in fasted state

4x250mg tablets, once in the morning, in fasted state

2x250mg tab, once in the morning, after being fed a high fat meal

4x125 mg tabs, once in the morning, in the fasted state. This arm will only occur as part of Part 2, if needed, pending results of Part 1.

4x125 mg IR once in the morning after being fed a high fat meal

2x250 mg controlled release formulation 5 tabs once in the morning in the fasted state

2x250 mg controlled release formulation 5 once in the morning after being fed a high fat meal