A Multiple Dose Trial Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of PF-04457845 in Healthy Volunteers

Oral solution of 0.5mg given once daily for 14 days.

Oral solution of 1mg given once daily for 14 days.

Oral solution of 4mg will be administered as a single dose 7-14 days prior to the multiple dosing phase where 4mg will be administered once daily for 14 days.

A randomized food treatment will be administered 7-14 days prior to and on day 1 of the multiple dosing phase

Oral solution of 8mg will be administered as a single dose 7-14 days prior to the multiple dosing phase where 8mg will be administered once daily for 14 days.

A randomized food treatment will be administered 7-14 days prior to and on day 1 of the multiple dosing phase