Neoadjuvant Study Investigating Degarelix in Patients Suffering From Prostate Cancer

PHASE3CompletedINTERVENTIONAL
Enrollment

246

Participants

Timeline

Start Date

April 30, 2009

Primary Completion Date

September 30, 2011

Study Completion Date

September 30, 2011

Conditions
Prostate Cancer
Interventions
DRUG

Degarelix

The degarelix doses were administered into the abdominal wall every 28 days. A starting dose of 240 mg (40 mg/mL) degarelix was administered on Day 0 as two 3 mL subcutaneous (s.c.) injections. The second and third doses of 80 mg (20 mg/mL) degarelix were administered as single 4 mL s.c. injections on Days 28 and 56, respectively.

DRUG

Goserelin

Goserelin implants (3.6 mg) were inserted s.c. into the abdominal wall every 28 days. The first dose was administered on Day 3. The second and third doses of goserelin were administered on Days 31 and 59, respectively.

DRUG

Bicalutamide

On Day 0, participants began once-daily per-oral (p.o.) treatment with bicalutamide (50 mg) as anti-androgen flare protection; this treatment continued for 14 days after the first dose of goserelin.

Trial Locations (66)

10016

University Urology Associates, New York

12601

Premier Medical Group of Hudson, Baldwinsville

13385

Hopital de la Timone, Marseille

14000

Centre Francois Baclesse, Caen

15126

"General Hospital of Athens, Sismanogleio, University of Athens, Marouse", Athens

22015

Clinique Saint Brieuc, Saint-Brieuc

23502

Urology of Virginia, Norfolk

24000

Clinique Francheville, Périgueux

25000

Hopital Jean Minjoz, Besançon

26504

University General Hospital of Patras, Pátrai

28046

Hospital Universitario La Paz, Madrid

31400

Clinique du Parc, Toulouse

33076

Institut Bergonié, Bordeaux

33180

South Florida Medical Research, Aventura

33449

Palm Beach Urology Associates, Wellington

33710

Pinellas Urology Inc., St. Petersburg

34747

DCT -Celebration, LLC dba Discovery Clinical Trials, Celebration

35209

Alabama Research Center, Birmingham

Urology Centers of Alabama, Homewood

37209

Urology Associates, Nashville

45110

University General Hospital of Loannina, Medical School, Loannina

46009

Fundación IVO, Valencia

46825

Northeast Indiana Research, Fort Wayne

47403

Summit Research Institute, Bloomington

59020

Centre Oscar Lambret, Lille

67085

Centre Paul Strauss, Strasbourg

68100

General University Hospital of Alexandroupolis, Alexandroupoli

69008

Centre Leon Berard, Lyon

75000

Hôpital Tenon, Paris

75010

Hôpital Saint Louis, Radiotherapy Departement, Paris

83100

Centre de radiologie Saint Louis, Toulon

85712

Arizona Urologic Specialists, Tuscon

86000

CHU La Milétrie, Oncology Radiotherapy, Poitiers

87109

Urology Group of New Mexico, Albuquerque

92563

Tri-Valley Urology Medical Group, Murrieta

92653

Orange County Urology, Lagua Hills

94000

CHU Henri Mondor, Créteil

94805

IGR, Villejuif

99508

Alaska Urological Association, Anchorage

06762

Connecticut Clinical Research Center, Middlebury

07631

Urology Center Research Institute, Englewood

CX5 34298

CRLC Val d'Aurelle Oncology Radiotherapy, Montpellier

Unknown

Centre de Lutte Contre le Cancer Nantes-Atlantique Centre René Gauducheau, Saint-Herblain

CX 42271

Institut de Cancérologie de la Loire, Saint-Priest-en-Jarez

D-12203

Charité-Universitätsmedizin, Campus Benjamin Franklin Klinik für Urologie, Berlin

D-38126

Städtisches Klinikum Braunschweig, Braunschweig

D-01307

Universitätsklinikum Dresden, Klinik und Poliklinik für Urologie, Dresden

D-89081

Universitätsklinikum Ulm, Klinik für Strahlentherapie und Radioonkologie, Ulm

3318 AT

Albert Schweitzer Ziekenhuis, Ioc., Dordwijk, Dordrecht

2803 HH

Groene Hart Ziekenhuis, urology, Gouda

3045 PM

Franciscus Gasthuis, Dept. urology, Rotterdam

3078HT

Maastad Ziekenhuis, Ioc. Clara, Rotterdam

3118 JH

Vlietland Ziekenhuis, Dept. urology, Schiedam

5000 LC

St. Elisabeth Ziekenhuis Tilburg, Tilburg

08025

Hospital de la Santa Creu i Sant Pau, Barcelona

08035

Hospital Universitari Vall d´Hebron, Barcelona

ME16 9QQ

Kent Oncology Centre Maidstone Hospital, Maidstone

HA6 2RN

Mount Vernon Cancer Center, Northwood

BA1 3NG

Oncology Royal United Hospital Bath NHS Trust, Bath

CB2 0QQ

Addenbrooke's Hospital, Oncology Centre, Cambridge

LS9 7TF

St. James' University Hospital, Leeds

SW3 6JJ

The Royal Marsden NHS, Foundation Trust, London

W6 8FR

Charing Cross Hospital, London

NE4 6BE

Northern Centre for Cancer Treatment, Newcastle General Hospital, Newcastle upon Tyne

SO16 6YD

Southhampton General Hospital, Cancer Care Directorate, Southhampton Oncology Centre, Southhampton

CF14 2TL

Velindre Hospital, Cardiff University, Whitchurch

Sponsors
All Listed Sponsors
lead

Ferring Pharmaceuticals

INDUSTRY

NCT00833248 - Neoadjuvant Study Investigating Degarelix in Patients Suffering From Prostate Cancer | Biotech Hunter | Biotech Hunter