1,089
Participants
Start Date
November 30, 2009
Primary Completion Date
March 31, 2013
Study Completion Date
June 30, 2013
sodium-selenite
An intravenous bolus of 1000 µg followed by a continuous intravenous infusion of 1000 µg/day until patient is discharged from the ICU but not more than 21 applications à 24 hours.
Placebo
An intravenous bolus of placebo followed by a continuous intravenous infusion with placebo until patient is discharged from the ICU but not more than 21 applications à 24 hours.
Procalcitonin guided therapy
"Causal therapy of sepsis is guided by applying the following algorithm:~Day 4: PCT drop from baseline \>=50%: no change in causal therapy; PCT drop from baseline \<50%: change or optimize antimicrobial therapy, new intervention (i.e. surgery, diagnostics) recommended for source control.~Day 7, 10, 14: PCT \<=1.0 ng/ml: finish antimicrobial therapy; PCT \>1.0 ng/ml and PCT drop from last PCT measurement \>=50%: finish antimicrobial therapy; PCT \>1.0 ng/ml and PCT drop from last PCT measurement \<50%: change or optimize antimicrobial therapy, new intervention (i.e. surgery, diagnostics) recommended for source control."
Military Hospital Berlin - Dep. of Anaesthesiology and Intensive Care Medicine, Berlin
Charité Berlin - Dep. of Anesthesiology and Intensive Care Medicine, Berlin
Vivantes Klinikum Neukölln - Dep. of Anesthesiology, Intensive Care Medicine and Pain Therapy, Berlin
DRK-Kliniken Berlin-Köpenick - Dep. of Anesthesiology, Pain Therapy, and Intensive Care Medicine, Berlin
Charité Berlin - Campus Virchow-Klinikum - Dep. of Nephrology, Berlin
Ernst-Moritz-Arndt-Universität Greifswald - Dep. of Anesthesiology and Intensive Care Medicine, Greifswald
Universitätsklinikum Hamburg-Eppendorf - Dep. of Intensive Care Medicine, Hamburg
University Hospital Kiel - Dep. of. Anesthesiology and Intensive Care Medicine, Kiel
Westküstenklinikum Heide - Dep. of Anesthesiology and Intensive Care Medicine, Heide
Klinikum Oldenburg GmbH - Dep. of Anesthesiology, Oldenburg
Ev. Krankenhaus Gilead - Dep. of Anesthesiology, Bielefeld
Georg August Universität Göttingen - Dep. of Anesthesiology and Intensive Care Medicine, Göttingen
University Hospital Münster - Dep. of Anesthesiology and Intensive Care Medicine, Münster
University Hospital Köln - Dep. of Medicine I, Cologne
St. Elisabeth-Krankenhaus - Dep. of Anesthesiology, Köln-Hohenlind
University Hospital Aachen - Dep. of Intensive Care Medicine, Aachen
University Hospital Bonn - Dep. of Anesthesiology and Intensive Care Medicine, Bonn
J.-W. Goethe University Hospital - Dep. of Anaesthesiology, Intensive Care Medicine and Pain Therapy, Frankfurt am Main
University Hospital Mannheim - Dep. of Medicine I, Mannheim
University Hospital Heidelberg - study center Anesthesiology/Surgery, Heidelberg
University Hospital Freiburg- Dep. of Surgery, Freiburg im Breisgau
University Hospital Munich - Dep. of Internal Medicine, Munich
University Hospital Munich - Dep. of Anaesthesiology, Munich
Hospital Munich Harlaching - Dep. of Internal Acute Medicine and Prevention, Munich
Krankenhaus München-Neuperlach - Dep. of Anesthesiology, München
Klinikum Augsburg - Dep. of Anesthesiology and Intensive Care Medicine, Augsburg
Klinikum Augsburg - Dep. of Medicine I, Augsburg
University Erlangen-Nürnberg - Dep. of Medicine IV, Erlangen
HELIOS Klinikum Erfurt - Dep. of Anesthesiology and Intensive Care Medicine, Erfurt
Krankenhaus Dresden-Friedrichstadt, Dresden
University Hospital Dresden - Dep. of Anesthesiology and Intensive Care Med., Dresden
Martin-Luther-Universität Halle-Wittenberg - Dep. of Anesthesiology, Halle
University Hospital Halle - Dep. of Medicine III, Halle
University Hospital Jena, Dep. of Anesthesiology and Intensive Care Medicine, Jena
University Hospital Leipzig - Dep. of Anesthesiology and Intensive Care Medicine, Leipzig
Collaborators (1)
Biosyn
INDUSTRY
Brahms AG
INDUSTRY
Kompetenznetz Sepsis
NETWORK