8
Participants
Start Date
March 31, 2009
Primary Completion Date
September 30, 2009
Study Completion Date
September 30, 2009
6β-Naltrexol escalating doses from 0.05-0.5 mg IV
"Drug: Naloxone 0.1 mg IV/5 minutes to all subjects to determine tolerability to precipitated withdrawal during screening. Those that tolerate withdrawal proceed to Stage 1:~Drug: Lactulose 10 gm orally plus 3 IV infusions 30 minutes apart of Naloxone 0.1 mg IV and 2 placebo given randomly to all subjects. If tolerated, proceed to 5 additional medication dosing sessions with all subjects receiving oral Lactulose 10 GM plus IV escalating 6β-Naltrexol 0.05 mg, 0.15 mg, 0.5 mg with a randomized placebo."
CPMC Addiction & Pharmacology Research Laboratory (APRL), San Francisco
California Pacific Medical Center Research Institute
OTHER