Efficacy and Safety of IPI-504 With Trastuzumab Pretreated, Locally Advanced or Metastatic HER2 Positive Breast Cancer

PHASE2TerminatedINTERVENTIONAL
Enrollment

29

Participants

Timeline

Start Date

March 31, 2009

Primary Completion Date

August 31, 2010

Study Completion Date

May 31, 2011

Conditions
Breast CancerHER2 Positive Breast CancerMetastatic Breast CancerCancer of the Breast
Interventions
DRUG

IPI-504

IPI-504 IV infusion 300 mg/m2

DRUG

Trastuzumab

Trastuzumab IV infusion 8 mg/kg as the first dose of trastuzumab, followed by trastuzumab 6 mg/kg every 3 weeks. Subjects whose last dose of trastuzumab was \<4 weeks prior to study entry will receive 6 mg/kg as the first dose of trastuzumab. For all additional cycles in Stage 1, trastuzumab will be administered with the first dose of IPI-504.

Trial Locations (11)

10065

Memorial Sloan-Kettering Cancer Center, New York

Weill Cornell Breast Center, New York

30318

Peachtree Hematology-Oncology Consultants, P.C., Atlanta

30912

Medical College of Georgia Cancer Center, Augusta

33328

Florida Cancer Research Institute, Davie

33431

Boca Raton Comphrensive Cancer Care, Boca Raton

38120

West Cancer Clinic, Memphis

76022

US Oncology, Dallas

92262

Comprehensive Cancer Center at Desert Regional Medical Center, Palm Springs

02115

Dana-Farber Cancer Institute, Boston

Unknown

Vall d'Hebron Institute of Oncology (V.H.I.O.), Barcelona

Sponsors
All Listed Sponsors
lead

Infinity Pharmaceuticals, Inc.

INDUSTRY

NCT00817362 - Efficacy and Safety of IPI-504 With Trastuzumab Pretreated, Locally Advanced or Metastatic HER2 Positive Breast Cancer | Biotech Hunter | Biotech Hunter