Comparative Study of Three NNRTI-Sparing HAART Regimens

PHASE3CompletedINTERVENTIONAL
Enrollment

1,814

Participants

Timeline

Start Date

May 31, 2009

Primary Completion Date

June 30, 2013

Study Completion Date

June 30, 2013

Conditions
HIV Infection
Interventions
DRUG

Emtricitabine/tenofovir disoproxil fumarate

200 mg emtricitabine/300 mg tenofovir disoproxil fumarate taken orally daily. A combination drug of two nucleoside reverse transcriptase inhibitors (NRTIs).

DRUG

Raltegravir

400 mg taken orally twice daily. An integrase inhibitor (INI).

DRUG

Darunavir

800 mg taken orally once daily. A protease inhibitor (PI).

DRUG

Ritonavir

100 mg taken orally once daily. A protease inhibitor (PI).

DRUG

Atazanavir

300 mg taken orally once daily. A protease inhibitor (PI).

Trial Locations (57)

10011

Cornell CRS, New York

10016

NY Univ. HIV/AIDS CRS, New York

10029

Metropolitan Hospital, New York

10032

HIV Prevention & Treatment CRS, New York

10457

Bronx-Lebanon Hosp. Ctr. CRS, The Bronx

11794

SUNY Stony Brook NICHD CRS (5040), Stony Brook

14607

AIDS Care CRS, Rochester

14642

Univ. of Rochester ACTG CRS, Rochester

15213

Pitt CRS, Pittsburgh

19104

Hosp. of the Univ. of Pennsylvania CRS, Philadelphia

20007

Georgetown University CRS (GU CRS), Washington D.C.

20060

Howard Univ. Washington DC NICHD CRS, Washington D.C.

21201

IHV Baltimore Treatment CRS, Baltimore

21287

Johns Hopkins Adult AIDS CRS, Baltimore

23219

Virginia Commonwealth Univ. Medical Ctr. CRS, Richmond

27401

Regional Center for Infectious Disease, Wendover Medical Center CRS (3203), Greensboro

27514

Unc Aids Crs, Chapel Hill

27710

Duke Univ. Med. Ctr. Adult CRS, Durham

30308

The Ponce de Leon Center CRS, Atlanta

32209

University of Florida Jacksonville (5051), Jacksonville

33136

Univ. of Miami AIDS CRS, Miami

33316

South Florida Childrens Diagnostic & Treatment Cen (5055), Fort Lauderdale

37203

Vanderbilt Therapeutics CRS, Nashville

43210

The Ohio State Univ. AIDS CRS, Columbus

44106

Case CRS, Cleveland

44109

Metro Health CRS, Cleveland

45267

Univ. of Cincinnati CRS, Cincinnati

48201

Wayne State Univ. CRS, Detroit

48202

Henry Ford Hosp. CRS, Detroit

60611

Northwestern University CRS, Chicago

60612

Rush Univ. Med. Ctr. ACTG CRS, Chicago

63110

Washington U CRS, St Louis

70112

Tulane University New Orleans NICHD CRS (5095), New Orleans

75208

Trinity Health and Wellness Center, Dallas

77030

Houston AIDS Research Team CRS, Houston

80045

University of Colorado Hospital CRS, Aurora

80204

Denver Public Health CRS, Denver

90033

USC CRS, Los Angeles

90035

UCLA CARE Center CRS, Los Angeles

90502

Harbor-UCLA Med. Ctr. CRS, Torrance

90806

Miller Children's Hospital, Long Beach

92103

Ucsd, Avrc Crs, San Diego

94110

Ucsf Aids Crs, San Francisco

94304

Stanford CRS, Palo Alto

97209

The Research & Education Group- Portland CRS (31474), Portland

98104

University of Washington AIDS CRS, Seattle

35294-2050

Alabama Therapeutics CRS, Birmingham

02114

Massachusetts General Hospital CRS, Boston

02115

Brigham and Women's Hosp. ACTG CRS, Boston

02118

Bmc Actg Crs, Boston

02215

Beth Israel Deaconess Med. Ctr., ACTG CRS, Boston

08103

Cooper Univ. Hosp. CRS, Camden

07103

New Jersey Medical School- Adult Clinical Research Ctr. CRS, Newark

02906

The Miriam Hosp. ACTG CRS, Providence

38105-2794

St. Jude/UTHSC CRS, Memphis

00927

San Juan City Hosp. PR NICHD CRS, Rio Piedras

00935

Puerto Rico-AIDS CRS, San Juan

Sponsors
All Listed Sponsors
collaborator

National Institute of Allergy and Infectious Diseases (NIAID)

NIH

collaborator

Bristol-Myers Squibb

INDUSTRY

collaborator

Gilead Sciences

INDUSTRY

collaborator

Merck Sharp & Dohme LLC

INDUSTRY

collaborator

Tibotec Therapeutics, a Division of Ortho Biotech Products, L.P., USA

INDUSTRY

lead

Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections

NETWORK