Tocolysis for Preterm Labor

NACompletedINTERVENTIONAL
Enrollment

301

Participants

Timeline

Start Date

June 30, 2004

Primary Completion Date

June 30, 2009

Study Completion Date

June 30, 2010

Conditions
Preterm Labor
Interventions
DRUG

1 Magnesium Sulfate

Participants randomized to this arm will receive a loading dose of 6gms intravenously followed by a maintenance dose of 2-4gm/hr, per physician discretion, until uterine quiescence is achieved. The Magnesium Sulfate dosage is then titrated down until discontinued per physician discretion.

DRUG

Nifedipine

Participants randomized to receive nifedipine will receive an initial 30mg loading dose, then 10 - 20mg q 4 - 6 hours as needed, per physician discretion, until uterine quiescence is achieved.

DRUG

Indomethacin

Participants randomized to receive indomethacin will receive an initial 100mg per rectum X1, may repeat x1, and then 25 - 50mg orally every 6 hours over 48 hours as needed per physician discretion until uterine quiescence has been achieved.

Trial Locations (1)

39216

The Winfred L. Wiser Hospital for Women and Infants at the University of Mississippi Medical Center, Jackson

All Listed Sponsors
lead

University of Mississippi Medical Center

OTHER

NCT00811057 - Tocolysis for Preterm Labor | Biotech Hunter | Biotech Hunter