A Study to Evaluate Efficacy and Safety of Oral BAY63-2521 in Patients With Pulmonary Arterial Hypertension (PAH)

PHASE3CompletedINTERVENTIONAL
Enrollment

445

Participants

Timeline

Start Date

December 17, 2008

Primary Completion Date

May 14, 2012

Study Completion Date

May 14, 2012

Conditions
Pulmonary Hypertension
Interventions
DRUG

Riociguat (Adempas, BAY63-2521)

BAY63-2521: 1mg tid - 2.5mg tid orally for 12 weeks

DRUG

Riociguat (Adempas, BAY63-2521)

BAY63-2521: 1.5mg tid orally for 12 weeks

DRUG

Placebo

Matching Placebo tid orally for 12 weeks

Trial Locations (122)

100

Taipei

1070

Bruxelles - Brussel

1090

Vienna

2010

Darlinghurst

2305

New Lambton Heights

3000

Leuven

3181

Prahran

4020

Linz

4029

Herston

4066

Auchenflower

6020

Innsbruck

7000

Royal Hobart Hospital, Hobart

8011

Christchurch

8091

Zurich

8200

Aarhus N

10032

New York

10043

Turin

10330

Bangkok

11217

Taipei

12808

Prague

14080

Mexico City

17475

Greifswald

20123

Milan

25030

Besançon

27100

Pavia

30625

Hanover

33604

Pessac

34059

Montpellier

34098

Istanbul

34149

Trieste

35392

Giessen

38000

Querétaro

38043

Grenoble

40202

Louisville

41013

Seville

43221

Columbus

44195

Cleveland

44280

Guadalajara

44670

Guadalajara

45014

Fairfield

45219

Cincinnati

50200

Chiang Mai

50924

Cologne

59037

Lille

64020

Monterrey

66421

Homburg

68131

Omaha

69126

Heidelberg

75390

Dallas

76031

Rouen

77030

Houston

79902

El Paso

80020

Culiacán

80045

Aurora

81377

München

85724

Tucson

90073

Los Angeles

92037

La Jolla

95817

Sacramento

100020

Beijing

100037

Beijing

119228

Singapore

121552

Moscow

168752

Singapore

197341

Saint Petersburg

200032

Shanghai

200433

Shanghai

510100

Guangzhou

813414

Kaohsiung City

4941492

Petah Tikva

02111

Boston

02115

Boston

02903

Providence

Unknown

Capital Federal

Ankara

90020 090

Porto Alegre

04012 180

São Paulo

04020-050

São Paulo

21941-913

Rio de Janeiro

T1Y 6J4

Calgary

M5G 2N2

Toronto

H3T 1E2

Montreal

F-29609

Brest

06200

Nice

01307

Dresden

04103

Leipzig

124 62

Chaïdári

00161

Rome

467-8602

Nagoya

910-1193

Yoshida

650-0017

Kobe

302-0022

Toride

305-8576

Tsukuba

920-8641

Kanazawa

252-0375

Sagamihara

980-8574

Sendai

901-0243

Tomigusuku

113-8655

Bunkyo-ku

181-8611

Mitaka

143-8541

Ōta-ku

160-8582

Shinjuku-ku

734-8551

Hiroshima

701-1192

Okayama

05-400

Otwock

3000-075

Coimbra

1169-024

Lisbon

1649-035

Lisbon

4099-001

Porto

03080

Seoul

03722

Seoul

05505

Seoul

06351

Seoul

08035

Barcelona

08036

Barcelona

581 85

Linköping

221 85

Lund

901 85

Umeå

35-100

Izmir

CB23 3RE

Cambridge

G81 4DY

Clydebank

NW3 2QG

London

W12 0HS

London

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Bayer

INDUSTRY