R-ICE and High-Dose Cyclophosphamide With PET/CT for Diffuse Large B-Cell Non-Hodgkin's Lymphoma

PHASE2TerminatedINTERVENTIONAL
Enrollment

27

Participants

Timeline

Start Date

January 31, 2009

Primary Completion Date

April 30, 2014

Study Completion Date

April 30, 2014

Conditions
Non-Hodgkin's Lymphoma
Interventions
BIOLOGICAL

Rituximab

375 mg/m\^2 on Day 1 of each cycle as part of R-CHOP or R-ICE. Also given 375 mg/m\^2 on Days 1, 30, and 37 as part of HiCy.

DRUG

Cyclophosphamide

750 mg/m\^2 on Day 1 of each cycle as part of R-CHOP.

DRUG

Doxorubicin

50 mg/m\^2 on Day 1 of each cycle as part of R-CHOP.

DRUG

Vincristine

1.4 mg/m\^2 on Day 1 of each cycle as part of R-CHOP.

DRUG

Prednisone

100 mg/day on Days 1-5 of each cycle as part of R-CHOP.

DRUG

Ifosfamide

2000 mg/m\^2/day on Days 1-3 of each cycle as part of R-CHOP.

DRUG

Carboplatin

Given on Day 2 of each cycle as part of R-CHOP. Dosed according to renal function.

DRUG

Etoposide

100 mg/m\^2/day on Days 1-3 of each cycle as part of R-CHOP.

DRUG

High-dose cyclophosphamide

50 mg/kg/day on Days 2-5 of HiCy.

PROCEDURE

PET scan

Performed once between Days 16-20 of cycle 3 of R-CHOP.

Trial Locations (1)

21231

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Genentech, Inc.

INDUSTRY

lead

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

OTHER

NCT00809341 - R-ICE and High-Dose Cyclophosphamide With PET/CT for Diffuse Large B-Cell Non-Hodgkin's Lymphoma | Biotech Hunter | Biotech Hunter