Ascending Multiple-Dose Study of Brivanib Alaninate in Combination With Chemotherapeutic Agents in Subjects With Advanced Cancers

PHASE1CompletedINTERVENTIONAL
Enrollment

111

Participants

Timeline

Start Date

March 31, 2009

Primary Completion Date

May 31, 2015

Study Completion Date

May 31, 2015

Conditions
Advanced Cancer
Interventions
DRUG

Capecitabine

Tablets, Oral, Dose escalation to a MTD from a starting dose of 850 mg/m², twice a day (BID) x 14d per cycle, until disease progression

DRUG

Doxorubicin

IV, Dose escalation to a MTD from a starting dose of 40 mg/m², Q3wks, until disease progression

DRUG

Ixabepilone

IV, Dose Escalation to a MTD from a starting dose of 32 mg/m², Q3wks, until disease progression

DRUG

Docetaxel

IV, Dose escalation to an MTD from a starting dose of 60 mg/m², Q3wks, Until disease progression

DRUG

Paclitaxel

IV, Dose escalation to an MTD from a starting dose of Paclitaxel 135 mg/m², Q3wks, Until disease progression

DRUG

Brivanib alaninate

Tablets, Oral, Dose escalation to a MTD from a starting dose of 400 mg, daily (QD), until disease progression

Trial Locations (5)

48201

Wayne State University, Detroit

90033

Usc/Norris Comprehensive Cancer Center, Los Angeles

02215

Dana Farber Cancer Institute, Boston

T6G 1Z2

Local Institution, Edmonton

M5G 2M9

Local Institution, Toronto

Sponsors
All Listed Sponsors
lead

Bristol-Myers Squibb

INDUSTRY