Vaccination of HIV-1 Infected Patients With Dendritic Cells in Addition to Antiretroviral Treatment - (DALIA Trial)

PHASE1CompletedINTERVENTIONAL
Enrollment

19

Participants

Timeline

Start Date

November 30, 2008

Primary Completion Date

September 30, 2011

Study Completion Date

September 30, 2011

Conditions
HIV
Interventions
BIOLOGICAL

Dendritic Cell Vaccine

"Biological/Vaccine: Experimental: Dendritic Cell Vaccine Patients will receive 4 doses of the vaccine at weeks 0, 4, 8 and 12. The vaccine will be injected subcutaneously, in 3 separate injection sites in the upper and lower extremities.~At week 24, patients will have HAART treatment interrupted. The HAART treatment will be resumed at week 48 or earlier at any time point if one of the following occur:~1. two consecutive measurements of CD4+ T cell count below 350x10e6 cells/L and/or 25% of total lymphocytes within at least a 2 weeks~2. an opportunistic infection~3. a CDC class C-defining event (defined in appendix 2)~4. a serious non-AIDS defining event.~Patients will have follow-up visits on weeks: 22, 24, 25, 26, 27, 28, 32, 36, 40, 44, and 48."

Trial Locations (1)

75204

Baylor University Medical Center, Dallas

Sponsors
All Listed Sponsors
collaborator

French National Agency for Research on AIDS and Viral Hepatitis

OTHER_GOV

lead

Baylor Research Institute

OTHER