An Efficacy and Safety Study of Trabectedin Versus Doxorubicin-Based Chemotherapy in Participants With Translocation-Related Sarcomas (TRS)

PHASE3CompletedINTERVENTIONAL
Enrollment

121

Participants

Timeline

Start Date

November 30, 2008

Primary Completion Date

August 31, 2012

Study Completion Date

August 31, 2014

Conditions
Sarcoma
Interventions
DRUG

Trabectedin

Trabectedin 1.5 milligram per square meter (mg/m\^2) will be given as 24-hour continuous intravenous infusion every 3 weeks until disease progression.

DRUG

Doxorubicin

Doxorubicin 60 or 75 mg/m\^2 will be given intravenously every 3 weeks until disease progression.

DRUG

Ifosfamide

Ifosfamide 6 to 9 g/m\^2 will be given intravenously every 3 weeks until disease progression.

Trial Locations (21)

Unknown

Santa Monica

Boston

Albuquerque

Philadelphia

Houston

Salt Lake City

Boreaux

Lille

Lyon

Paris

Villejuif

Bad Saarow

Cologne

Mannheim

Barcelona

Palma

Valencia

Edinburgh

Glasgow

London

Manchester

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

PharmaMar

INDUSTRY

lead

Johnson & Johnson Pharmaceutical Research & Development, L.L.C.

INDUSTRY