Bevacizumab and Carmustine in Treating Patients With Relapsed or Progressive High-Grade Glioma

PHASE2CompletedINTERVENTIONAL
Enrollment

7

Participants

Timeline

Start Date

June 30, 2008

Primary Completion Date

December 31, 2015

Study Completion Date

December 31, 2015

Conditions
Glioma
Interventions
DRUG

bevacizumab

Bevacizumab (10 mg/kg) will be given intravenously every other week starting one week before the first dose of BCNU. Treatment with both BCNU and bevacizumab for 6-months, after which the participant may continue to receive bevacizumab every 2 weeks for a maximum of one year and three additional cycles of BCNU.

DRUG

carmustine

BCNU (200 mg/m2), will be given over 4 hours as a continuous intravenous infusion every 8 weeks. Treatment with both BCNU and bevacizumab for 6-months, after which the participant may continue to receive bevacizumab every 2 weeks for a maximum of one year and three additional cycles of BCNU.

Trial Locations (1)

95817

University of California Davis Cancer Center, Sacramento

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

collaborator

Genentech, Inc.

INDUSTRY

lead

University of California, Davis

OTHER

NCT00795665 - Bevacizumab and Carmustine in Treating Patients With Relapsed or Progressive High-Grade Glioma | Biotech Hunter | Biotech Hunter