Effects of Vaccinations With HLA-A2-Restricted Glioma Antigen-Peptides in Combination With Poly-ICLC for Adults With High-Risk WHO Grade II Astrocytomas and Oligo-Astrocytomas

EARLY_PHASE1CompletedINTERVENTIONAL
Enrollment

13

Participants

Timeline

Start Date

January 31, 2009

Primary Completion Date

February 28, 2013

Study Completion Date

July 31, 2015

Conditions
AstrocytomaOligo-AstrocytomaGlioma
Interventions
BIOLOGICAL

GAA/TT-peptide vaccine and poly-ICLC

Participants will be treated with subcutaneous injections of GAA/TT-vaccines on Weeks 0, 3, 6, 9, 12, 15, 18 and 21. I.m. poly-ICLC will be administered (20 mg/kg i.m.) on the day of, and on day 4 after each vaccine (e.g. if the vaccine is administered on Thursday, poly-ICLC will be administered on the day of vaccine and the following Monday). Each vaccine will be administered within 2 hours before or after the i.m. poly-ICLC administration.

BIOLOGICAL

GAA/TT-peptide vaccine and poly-ICLC

Participants will be treated with subcutaneous injections of GAA/TT-vaccines on Weeks 0, 3, 6, 9, 12, 15, 18 and 21. I.m. poly-ICLC will be administered (20 mg/kg i.m.) on the day of, and on day 4 after each vaccine (e.g. if the vaccine is administered on Thursday, poly-ICLC will be administered on the day of vaccine and the following Monday). Each vaccine will be administered within 2 hours before or after the i.m. poly-ICLC administration.

Trial Locations (2)

15232

University of Pittsburgh Cancer Institute, Pittsburgh

27157-1030

Comprehensive Cancer Center of Wake Forest University, Winston-Salem

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Oncovir, Inc.

INDUSTRY

collaborator

National Cancer Institute (NCI)

NIH

lead

Ian F. Pollack, M.D.

OTHER

NCT00795457 - Effects of Vaccinations With HLA-A2-Restricted Glioma Antigen-Peptides in Combination With Poly-ICLC for Adults With High-Risk WHO Grade II Astrocytomas and Oligo-Astrocytomas | Biotech Hunter | Biotech Hunter