Lenalidomide and Low-Dose Dexamethasone in Patients With Previously Treated Multiple Myeloma and Kidney Dysfunction

PHASE1/PHASE2TerminatedINTERVENTIONAL
Enrollment

63

Participants

Timeline

Start Date

January 21, 2009

Primary Completion Date

September 30, 2017

Study Completion Date

March 8, 2018

Conditions
Multiple MyelomaPlasma Cell Neoplasm
Interventions
DRUG

Lenalidomide

Given by mouth days 1-21 of a 28-day cycle. There is a 7 day rest (days 22-28). Continue until disease progression or unacceptable toxicity.

DRUG

Dexamethasone

40 mg given by mouth days 1, 8, 15 and 22 of a 28-day cycle. Continue until disease progression or unacceptable toxicity.

DRUG

Anticoagulants

Anticoagulation consisted of aspirin at either 81 mg/day or 325 mg/day at the physician's discretion. Heparin, low molecular weight heparin, or coumadin could be used if the patient was intolerant to aspirin.

Trial Locations (16)

19611

Reading Hospital and Medical Center, West Reading

26506

WVU Mary Babb Randolph Cancer Center, Morgantown

28501

Kinston Medical Specialists, Kinston

30322

Emory University Winship Cancer, Atlanta

50010

McFarland Clinic, Ames

51101

Siouxland Hematology Oncology Associates, Sioux City

53188

Waukesha Memorial Hospital (ProHealth Care), Waukesha

53226

Aurora Cancer Center, Wauwatosa

54601

Gundersen Lutheran, La Crosse

55416

Metro MN CCOP, Saint Louis Park

55905

Mayo Clinic, Rochester

60612

University of IL at Chicago, Chicago

68106

Missouri Valley Cancer Consortium, Omaha

85259-5499

Mayo Clinic in Arizona, Scottsdale

48106-0955

Michigan Cancer Research Consortium and Oncology Research- St. Joseph Mercy Hospital - Ann Arbor, Ann Arbor

19104-4283

University of Pennsylvania, Philadelphia

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Celgene

INDUSTRY

lead

PrECOG, LLC.

OTHER