Efficacy and Safety of Everolimus (RAD001) in Patients of All Ages With Subependymal Giant Cell Astrocytoma Associated With Tuberous Sclerosis Complex (TSC)(EXIST-1)

PHASE3CompletedINTERVENTIONAL
Enrollment

117

Participants

Timeline

Start Date

August 31, 2009

Primary Completion Date

March 31, 2011

Study Completion Date

October 31, 2014

Conditions
Tuberous SclerosisSubependymal Giant Cell Astrocytoma
Interventions
DRUG

Everolimus

Everolimus was formulated as tablets of 1.0-mg strength and was blisterpacked under aluminum foil in units of 10 tablets.

DRUG

Placebo

Placebo was provided as a matching tablet and was blisterpacked under aluminum foil in units of 10.

Trial Locations (24)

1090

Novartis Investigative Site, Brussels

2130

Novartis Investigative Site, Randwick

13353

Novartis Investigative Site, Berlin

16147

Novartis Investigative Site, Genova

22031

Children's Regional Outpatients Center SC, Fairfax

30342

Children's Healthcare of Atlanta, Atlanta

35294

University of Alabama at Birmingham, Birmingham

69120

Novartis Investigative Site, Heidelberg

75219

Texas Scottish Rite Hospital for Children, Dallas

85013

Barrow Tuberous Sclerosis Center, Phoenix

90048

University of California at Los Angeles, Los Angeles

127412

Novartis Investigative Site, Moscow

94609-1809

Children's Hospital Oakland Hematology/Oncology Dept, Oakland

60637-1470

University of CHicago Comer Children's Hospital, Chicago

02114

Massachusetts General Hospital Mass General, Boston

02115

Children's Hospital Boston SC-1, Boston

55102-2383

Minnesota Epilepsy Group - PA, Saint Paul

45229-3039

Cincinnati Children's Hospital Medical Center Cincinnati Children's Hosp, Cincinnati

M5G 1X8

Novartis Investigative Site, Toronto

H3T IC5

Novartis Investigative Site, Québec

00137

Novartis Investigative Site, Roma

3584CX

Novartis Investigative Site, Utrecht

04-730

Novartis Investigative Site, Warsaw

BS1 3NU

Novartis Investigative Site, Bristol

Sponsors
All Listed Sponsors
lead

Novartis Pharmaceuticals

INDUSTRY