24
Participants
Start Date
March 31, 2007
Primary Completion Date
March 31, 2007
Study Completion Date
March 31, 2007
Midazolam Alone
Midazolam 2 mg syrup was given orally after a fast of at least 10 hours.
Qualaquin (quinine) alone steady state
Qualaquin (quinine) 324 mg capsules were given orally every 8 hours for 7 days ( 21 doses total). On day 9 after taking Qualaquin (quinine) for 5 days according to the stated regimen and fasting for at least 10 hours, all participants took their usual dose of Qualaquin (quinine). Blood was drawn at times sufficient to characterize the pharmacokinetics of quinine at steady state
Midazolam and Qualaquin at steady state
On the morning of day 10 after taking Qualaquin (quinine) for 6 days according to the stated regimen (324 mg every 8 hours), all participants took their usual dose of Qualaquin (quinine) with an oral dose of midazolam 2 mg after a fast of at least 10 hours
MDS Pharma Services, Phoenix
Lead Sponsor
Mutual Pharmaceutical Company, Inc.
INDUSTRY