A Clinical Study for Patients With Neurogenic Orthostatic Hypotension (NOH) Using Droxidopa

PHASE3CompletedINTERVENTIONAL
Enrollment

263

Participants

Timeline

Start Date

September 30, 2008

Primary Completion Date

September 30, 2010

Study Completion Date

September 30, 2010

Conditions
Symptomatic Neurogenic Orthostatic Hypotension (NOH)Non-diabetic NeuropathyPrimary Autonomic FailureDopamine Beta Hydroxylase Deficiency
Interventions
DRUG

Placebo

100 mg, oral, three times per day 200 mg, oral, three times per day 300 mg, oral, three times per day 400 mg, oral, three times per day 500 mg, oral, three times per day 600 mg, oral, three times per day

DRUG

Droxidopa

100 mg, oral, three times per day 200 mg, oral, three times per day 300 mg, oral, three times per day 400 mg, oral, three times per day 500 mg, oral, three times per day 600 mg, oral, three times per day

Trial Locations (21)

11030

North Shore Hospital, Manshasette

19013

HAN Neurological Associates, Upland

19107

Pennsylvania Hospital of the University of PA Health System- Department of Neurology, Philadelphia

20892

Cncs, Ninds,Nih, Bethesda

33701

Suncoast Neuroscience Associates, Inc, St. Petersburg

34205

Bradenton Neurology, Inc, Bradenton

35801

North Alabama Neuroscience, Huntsville

39401

Nerological Reserch Center at Hattiesburg, Hattiesburg

66160

University of Kansas Medical Center, Kansas City

72205

Arkansas Cardiology, Little Rock

77030

Baylor College of Medicine, Houston

85340

Mayo Clinic-Arizona, Scottsdale

92697

University of California, Irvine, Irvine

98034

Evergreen Hospital Medical Center; Booth Gardner Parkinson's Care Center, Kirkland

T2N 4N1

University of Calgary, Calgary

T5G 0B7

University of Alberta, Edmonton

R3J 2H7

Movment Disorder Clinic Deer lodge Centre, Winnipeg

GB3J 3T1

David B. King, - Private Clinic, Halifax

N6A 5A5

London Health Sciences Centre, UH, London

M5T 2S8

UHNresearch, Toronto

H2W 1 R7

IRCM, Montreal

Sponsors
All Listed Sponsors
collaborator

Chiltern International Inc.

INDUSTRY

lead

Chelsea Therapeutics

INDUSTRY